Kalanchoe thyrsiflora forms a basal rosette of large rounded, fleshy leaves, which are greyish cream with red margins. With the inflorescence, the plants reach about 1 m. The erect, upward facing, tightly arranged leaves are without petioles.
Plant in a well-drained soil in full sun. Do not overwater.
Kalanchoe thyrsiflora occurs from the central to the southern escarpment and the foothills in bushveld habitats.